Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics.  It has effects similar to the phenothiazines .  The drug binds preferentially to D 2 and α 1 receptors at low dose (ED 50 = and mg/kg, respectively), and 5-HT 2 receptors at a higher dose (ED 50 = mg/kg). Given that antagonism of D 2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT 2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis.  Haloperidol's negligible affinity for histamine H 1 receptors and muscarinic M 1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain, and orthostatic hypotension though having higher rates of treatment emergent extrapyramidal symptoms .
I’m on my second round of being a caretaker of an advanced Alzheimer’s patient. My father has passed on and I am now taking care of his sister, my aunt, who is eighty six. My advice, through experience, give them food when they want it and pick your battles. It is easier to agree than to argue. If you have to tell them they need to go to bed because we have to get up for church in the morning, do it. Every day could be Sunday here. There are times where they have had extreme clarity and times they have no clue who I was. My aunt always wants to go “home”, thousands of miles from my house where she now lives. We have used the term vacation as the reason she is here many times. As well as Alzheimer’s, she is basically a walking, or should I say shuffling, miracle as MRI’s of her spine show that her back is pretty well burnt toast. She is in pain, but yet when I take her to the doctor she states she is not. I have used video to show the doctor that what I am saying about her pain is true. On video she will go from a pain level of 10 to zero in a matter of minutes, but she is in pain. The video was the only way to convince the doctor, besides demanding and MRI. We have “baby” alarms on the doors and when she figured out how to knock the batteries out of them we put on the “baby” door knob covers – these have worked. We take the knobs off the stove at night to keep her from blowing us up as well, and the sliding glass door has a pair of vice grips along the track at the top to keep her in. Double keyed dead bolts where a key is needed to open from the inside and out will also keep a loved one indoors during the night. My opinion, and my opinion only, is that it is my job to take care of her, I refuse to fight and try to find humor in the repetition or demands – it is pretty easy to redirect someone in her condition to change the subject, and it often works. The fact is… she is dying a slow death and I want to make her as comfortable as possible. If the house is Auntie proofed, she can’t hurt herself or get out in the middle of the night and I can get my sleep too. I would much rather have her here with me than in a home. Most homes I have visited I wouldn’t let my dog live in. God bless you all for all you do, you are earning you wings. Good luck.
my mother is 83 yrs old, has dementia/alzhiemers. She is in a nursing facility and they have been giving her Haldol when needed, recently they started giving it to her twice daily and as needed. For the past 3 weeks now she has become incoherant most of the time, makes no sense when talking, can hardly walk and will NOT sleep at night. She is exremely anxious, not wanting to sit still for any length of time. Her tongue is constantly out and moving. I'm wondering why they keep giving it to her when the FDA does not recommend it. Has anyone else had this problem. I don't want her to die because the nursing facility doesn't have the time or staff to tend to her. They tell me if they take her off this medication and she "acts" out they will remove her from the facility.