DHEA is transformed into DHEA-S by sulfation at the C3β position via the sulfotransferase enzymes SULT2A1 and to a lesser extent SULT1E1 .    This occurs naturally in the adrenal cortex and during first-pass metabolism in the liver and intestines when exogenous DHEA is administered orally. [ citation needed ] Levels of DHEA-S in circulation are approximately 250 to 300 times those of DHEA.  DHEA-S in turn can be converted back into DHEA in peripheral tissues via steroid sulfatase (STS).  
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Liven-Up Your Sexual Health* Proper hormone function is incredibly useful for any fitness goal because your hormone levels can dictate how efficient your body is operating. Whether burning fat or building muscle, dietary DHEA supplementation may support proper hormone levels in the body and aid in overall well being, daily energy, and libido.*