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Both polar and non-polar substances diffuse via transcellular and intercellular routes by different mechanisms. The polar molecules mainly diffuse through the polar pathway consisting of “bound water” within the hydrated stratum corneum whereas the non-polar molecules dissolve and diffuse through the non-aqueous lipid matrix of the stratum corneum . Thus the principal pathway taken by a penetrant is decided mainly by the partition coefficient (log K). Hydrophilic drugs partition preferentially into the intracellular domains, whereas lipophillic permeants (octanol/water log K > 2) traverse the stratum corneum via the intercellular route. Most molecules pass the stratum corneum by both routes. 5

Primobolan cycle can be a reason for the next side effects:

  1. acne
  2. accelerated hair loss
  3. body hair growth
  4. virilization in women(manifested by hair growth in various areas of the body, a deepenedvoice and an enlargement of the clitoris),
  5. a mild enhancement of blood pressure levels
  6. violations of cholesterol levels
  7. curbing of testosterone production
  8. hepatic stress
  9. a low level of liver toxicity

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