Yes. People with diabetes should wear identification stating they have diabetes and whether they have recurrent low blood sugar. Those at risk for the health condition should be counseled on checking blood sugars before they drive a car, operate heavy machinery, or do anything physically taxing. In addition, it is important to carry a quick-acting glucose source (such as those mentioned above) at all times, and keep a source in their car, office, and by their bedside. Efforts should be made to minimize the hypoglycemic effects of drug regimens and to avoid variable surges in exercise , activity, and drinking alcohol.
Theophylline: The pharmacokinetics of theophylline were determined from a single intravenousdose of aminophylline (6 mg/kg) before and after the oral administration of Fluconazole 200 mg daily for 14 days in 16 normal male volunteers. There were significant increases in theophylline AUC, C max , and half-life with a corresponding decrease in clearance. The mean ± SD theophylline AUC increased 21% ± 16% (range: –5 to 48%). The C max increased 13% ± 17% (range: –13 to 40%). Theophylline clearance decreased 16% ± 11% (range: –32 to 5%). The half-life of theophylline increased from ± hours to ± hours. (See PRECAUTIONS.)
Stead et al (2008) performed a systematic review and meta-analysis of mechanical thrombectomy in the treatment of ischemic stroke and assessed factors for technical and clinical success and survival. These researchers searched the literature using Medline and Embase for January 1, 2000 through March 1, 2006. Studies were limited to those in human beings; there were no language or study design restrictions. Validity assessment was performed using the Newcastle-Ottawa Scale. The pooled cohort was compared with a historical cohort matched for sex, age, and NIHSS. The search yielded 114 publications. Two authors determined inclusibility (inter-rater agreement, kappa = ). Mean pre-procedure NIHSS score was . The MCA (36 %) and the posterior circulation (38 %) were the most frequently occluded areas. The clot was accessible in 85 % of the patients. Hemorrhage occurred in 22 % of the patients. Of 81 patients with concurrent thrombolysis, % had hemorrhage compared with % of 66 patients without thrombolysis (p = ). Of the 126 patients with accessible clots, 36 % had a good mRS (less than or equal to 2) and 29 % died; in patients with inaccessible clots, 24 % had a good mRS and 38 % died. Factors associated with clinical success were younger age (p = ) and lower NIHSS score at admission to the hospital (p = ). Compared with a matched cohort, patients who received mechanical intervention were times more likely to have a good mRS (95 % CI: to ; p < ). The authors concluded that percutaneous mechanical embolectomy in the treatment of AIS is feasible and seems to provide an option for some patients seen after the interval for administration of IV tPA therapy has elapsed.