The brands from this section are the top products we recommend to our readers and the guys we are training. We’ve picked them because they’ve worked not only for the people from which we’ve received reviews from, but they’ve worked for us, as we are personally using each one of them. These are mostly pure testosterone boosters and multi-purpose products with testosterone boosting abilities and they are the best products in our personal opinion and are highly recommended by our team. Most of the products on this list usually provide a free sample, so you can try them before you are totally convinced that they are working for you.
Hiya, I found this article while trying to find a solution to my bf’s low libido and low prolactin levels as we are trying to conceive. He is currently taking mg SAMe in the am, B6 Pyridoxine, Vitamin E (d-alpha tocopherol) and Zinc orotate during the day & Mucuna pruriens 30 mins before bed. He has been taking these for 10 days and has experienced some anxiety and mood swings along with heart palpitations. Do you think this is the SAMe causing these symptoms? How long would you recommend he take all supplements for it to have a lasting effect on his libido and prolactin levels but to stay safe? Id really appreciate your advice. Thank you. 🙂
Because of its anabolic effects on muscle, testosterone is being explored as a function-promoting anabolic therapy for functional limitations associated with aging; however, concerns about testosterone's adverse effects on prostate have inspired efforts to develop strategies that selectively increase muscle mass while sparing the prostate. Testosterone's promyogenic effects are mediated through upregulation of follistatin. We show here that the administration of recombinant follistatin (rFst) increased muscle mass in mice, but had no effect on prostate mass. Consistent with the results of rFst administration, follistatin transgenic mice with constitutively elevated follistatin levels displayed greater muscle mass than controls, but had similar prostate weights. To elucidate signaling pathways regulated differentially by testosterone and rFst in prostate and muscle, we performed microarray analysis of mRNAs from prostate and levator ani of castrated male mice treated with vehicle, testosterone, or rFst. Testosterone and rFst shared the regulation of many transcripts in levator ani; however, in prostate, 593 transcripts in several growth-promoting pathways were differentially expressed after testosterone treatment, while rFst showed a negligible effect with only 9 transcripts differentially expressed. Among pathways that were differentially responsive to testosterone in prostate, we identified ornithine decarboxylase (Odc1), an enzyme in polyamine biosynthesis, as a testosterone-responsive gene that is unresponsive to rFst. Accordingly, we administered testosterone with and without α-difluoromethylornithine (DFMO), an Odc1 inhibitor, to castrated mice. DFMO selectively blocked testosterone's effects on prostate, but did not affect testosterone's anabolic effects on muscle. Co-administration of testosterone and Odc1 inhibitor presents a novel therapeutic strategy for prostate-sparing anabolic therapy.