Other permanent side effects are similar to many other typical antipsychotics, namely extrapyramidal symptoms as a result of dopamine blockade in subcortical areas of the brain. This may result in symptoms similar to those seen in Parkinson's disease and include a restlessness and inability to sit still known as akathisia , a slow tremor and stiffness of the limbs.  Zuclopenthixol is thought to be more sedating than the related flupentixol , though possibly less likely to induce extrapyramidal symptoms than other typical depots.  As with other dopamine antagonists, zuclopenthixol may sometimes elevate prolactin levels; this may occasionally result in amenorrhoea or galactorrhoea in severe cases. Neuroleptic malignant syndrome is a rare but potentially fatal side effect. Any unexpected deterioration in mental state with confusion and muscle stiffness should be seen by a physician.
Finally, this book is intended to be genuinely helpful for practitioners of psychopharmacology by providing them with the mixture of facts and opinions selected by the author. Ultimately, prescribing choices are the reader’s responsibility. Every effort has been made in preparing this book to provide accurate and up-to-date information in accord with accepted standards and practice at the time of publication. Nevertheless, the psychopharmacology field is evolving rapidly and the author and publisher make no warranties that the information contained herein is totally free from error, not least because clinical standards are constantly changing through research and regulation. Furthermore, the author and publisher disclaim any responsibility for the continued currency of this information and disclaim all liability for any and all damages, including direct or consequential damages, resulting from the use of information contained in this book. Doctors recommending and patients using these drugs are strongly advised to pay careful attention to, and consult information provided by, the manufacturer.
- arteriosclerosis, a disease affecting the arteries
- convulsions, fits or seizures
- decreased blood supply to the brain
- diabetes, a disorder of metabolism in which the amount of sugar in the blood is too high
- feeling lethargic, indifferent, lost or remote
- glaucoma, a condition in which there is usually a build-up of pressure in the eye
- heart and blood vessel problems
- kidney problems
- liver problems
- low potassium and/or low magnesium levels in the blood
- organic brain syndrome
- parkinsonism, a disease of the brain affecting movement
- risk factors for stroke
- tardive dyskinesia, a reaction to some medicines with worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks or jaw which may progress to the arms and legs.
- treatment for cancer
- if you or someone else in your family has a history of blood clots, as medicines like these have been associated with formation of blood clots